1. The skull geometry of the anencephalic fetuses was different from normal proportions: anencephalic fetuses showed a clear mandibular prognathism, and a maxilla tilted in anterior direction.

2. Craniofacial dysostosis an autosomal dominant condition marked by a pointed or conical skull, protruding wide-set eyes, strabismus, parrot-beaked nose, and hypoplastic maxilla with relative mandibular prognathism